"Tl'esqox" is the Tŝilhqot’in name for this creek meaning 'muddy creek' - where the subject "gwetl’es" means 'muddy place’ and the suffix "-qox" (from "yeqox") means 'creek/river.' This name refers to the creek as well as the wider locality of the drainage area of that creek (Advice from the Tŝilhqot'in National Government, 2018).
Source: BC place name cards & correspondence, and/or research by BC Chief Geographer & Geographical Names Office staff.